Genetic susceptibility to endomyocardial fibrosis

Genetic susceptibility to endomyocardial fibrosis

BACKGROUND Endomyocardial fibrosis (EMF) is the most common form of restrictive cardiomyopathy worldwide. It has been linked to poverty and various environmental factors, but-for unknown reasons-only some people who live in similar conditions develop the disease. EMF cases cluster within both families and ethnic groups, suggesting a role for a genetic factor in host susceptibility. The human le...

Endomyocardial fibrosis

Loeffler endomyocardial fibrosis.

Electrocardiogram in Endomyocardial Fibrosis

Endomyocardial fibrosis (EMF) is a distinct obliterative cardiomyopathy characterized anatomically by right/left/bi ventricular endocardial fibrotic thickening and varying degrees of obliteration of the ventricular cavity. Chamber obliteration leads to diastolic restriction to ventricular filling and thus diastolic ventricular dysfunction. Involvement of the chordae tendinae and papillary muscl...

Endomyocardial fibrosis in Africa.

Endomyocardial fibrosis (EMF) is a disease of the rain-forest belt in Africa. There is general agreement as to its pathology in the acute phase, but this is difficult to diagnose clinically. The aetiology is still unknown although there are reports which suggest that eosinophilic endomyocardial disease may be the cause. Further studies are needed to define EMF in its acute stage and find out ho...